Mesalazine induced interstitial nephritis.
نویسندگان
چکیده
5-Aminosalicylic acid (5-ASA) has structural similarities to both phenacetin and aspirin, which are known to cause 'analgesic nephropathy'. Because of the increasing use of 5-ASA, this paper draws attention to two cases of severe interstitial nephritis resulting from 5-ASA and emphasises the importance of monitoring renal functions of patients with inflammatory bowel diseases who are receiving 5-ASA preparations.
منابع مشابه
Pediatric case of mesalazine-induced interstitial nephritis with literature review.
We present the case of a 14-year-old boy with ulcerative colitis who was diagnosed with mesalazine-induced interstitial nephritis (M-IIN). Improvement in renal function occurred with discontinuation of mesalazine and corticosteroid therapy. We systematically searched the literature for pediatric cases of M-IIN. There were eight cases. Majority of the cases were boys (75%) with ulcerative coliti...
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Background: 5-Aminosalicylates are extensively prescribed for the treatment of ulcerative colitis but have a wide range of described adverse effects. Aims: To determine whether serious adverse effect profiles differ for sulphasalazine and mesalazine. Methods: Analysis of suspected serious adverse reactions reported to the Committee on Safety of Medicines of the UK in 1991–1998. Adverse effect p...
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5-Aminosalicyiic acid (5-ASA) is the most commonly used drug for the treatment of inflammatory bowel disease (IBD). 5aminosalicylic acid induced nephrotoxicity has recently been reported. We report a case of female with Crohn's disease treated with mesalazine for 60 months and sulphasalazine for additional 12 months. The patient presented with loin pain, sterile pyuria and raised serum creatini...
متن کاملMesalazine-induced interstitial nephritis in a patient with ulcerative colitis.
1 of 2 DESCRIPTION A 25-year old male with a 10-year history of ulcerative colitis (UC), maintained on clinical remission with mesalazine (1.5 g/day) presented with 1-week history of progressive fatigue and nausea. He had no other symptoms such as fever, arthralgia or skin rashes. He was found to be in renal failure with the following laboratory parameters: serum creatinine 13.9 mg/dl, urea 138...
متن کاملRecurrent Interstitial Pneumonitis in a Patient with Entero-Behçet's Disease Initially Treated with Mesalazine
A 65-year-old man with entero-Behçet's disease (BD) being treated with mesalazine was presented to our hospital complaining of dyspnea. Computed tomography (CT) of the chest showed ground-glass opacities and he was initially diagnosed with mesalazine-induced interstitial pneumonitis (IP). Besides the discontinuation of mesalazine, a high dose of oral prednisolone was administered and the patien...
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ورودعنوان ژورنال:
- Gut
دوره 35 10 شماره
صفحات -
تاریخ انتشار 1994